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Ketamine is primarily metabolized to norketamine by hepatic CYP2B6 and CYP3A4-mediated N-demethylation. However, the relative contribution from each enzyme remains controversial. The CYP2B6*6 allele is associated with reduced enzyme expression and activity that may lead to interindividual variability in ketamine metabolism. We examined the N-demethylation of individual ketamine enantiomers usin...
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Deconvoluting the molecular target signals behind observed drug response phenotypes is an important part of phenotype-based drug discovery and repurposing efforts. We demonstrate here how our network-based deconvolution approach, named target addiction score (TAS), provides insights into the functional importance of druggable protein targets in cell-based drug sensitivity testing experiments. U...
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The legal and political concepts of constitutionalism are of great importance in the thoughts of the thinkers of that revolution. These concepts need to be defined and explained, because in most works related to constitutionalism; this aspect of their views has not been addressed. The notion of parliament is one of these very important concepts. Akhund Khorasani, as one of the leaders of the Co...
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Disaster concentrates the mind wonderfully. The Shelton tragedy forced M.P.s to grapple with mental illness once more in Parliament's spring term after a long lull in which national economic troubles claimed their attention to the exclusion of almost all else. Mr. Kenneth Robinson, the Minister of Health, finally agreed ?and to be fair, without too much reluctance?to hold the Shelton inquiry in...
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cement is an essential ingredient in the concrete buildings. for production of cement considerable amount of fossil fuel and electrical energy is consumed. on the other hand for generating one tone of portland cement, nearly one ton of carbon dioxide is released. it shows that 7 percent of the total released carbon dioxide in the world relates to the cement industry. considering ecological issu...
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ژورنال
عنوان ژورنال: The English Historical Review
سال: 1901
ISSN: 0013-8266,1477-4534
DOI: 10.1093/ehr/xvi.lxiii.499